Which comes first in Alzheimer's - amyloid beta or tau?

New PET technologies that can see pathological proteins are unravelling disease progression

Harvard researchers think they have found the order in which protein pathology occurs in Alzheimer’s disease, with tau protein appearing to be the most closely connected with mild cognitive impairment.

CT scanner

They suggest that sequential use of the new PET technology that can show tau protein neurofibrillary tangles in the brain may eventually become standard to track disease progression.

However, writing in JAMA Neurology, they caution that their results are based on findings in just a handful of patients and need to be replicated.