Who should be screened for familial Paget’s disease?

The longest follow-up yet of relatives shows only a handful go on to develop the condition
Clare Pain
phlebologist holding a tube of blood

Close relatives of people with familial Paget’s disease of bone who carry mutations in the sequestosome 1 gene are probably the only people worth screening for the disease, a Dutch study suggests.

Even so, their chance of developing the condition appears to be low, the results show.