Will this pre-eclampsia trial change guidelines?
The largest study yet suggests that expectant management may not be the best approach
Offering a planned early delivery to women with late preterm pre-eclampsia reduces maternal morbidity without adversely affecting neonatal morbidity, UK trial results show.
In the largest trial to date, 901 pregnant women with late-term pre-eclampsia from 34 to 37 weeks’ gestation were randomly allocated to either planned delivery within two days of randomisation or usual care (expectant management).
Participants (mean age, 31) were recruited at 46 maternity units across England and Wales.
Overall, fewer women in the planned delivery arm (65%) experienced the major maternal outcome of a composite of systolic BP above 160mmHg at any time after randomisation and events measured by the fullPIERS pre-eclampsia outcomes.
