Infertility is one of the most common chronic diseases in those of reproductive age, affecting approximately one in every six individuals of reproductive age worldwide.¹ 

It is estimated that 30% of infertile heterosexual couples are affected by unexplained infertility (UI), which is a diagnosis of exclusion, based on the absence of abnormalities of the female and male reproductive systems after ‘standard’ investigations.²

The 2024 Australian Evidence-based Guideline for Unexplained Infertility, approved by the NHMRC, provides clinicians with evidence-based recommendations for the optimal diagnostic workup and therapeutic approach to couples with UI.^3,4

This article aims to highlight the elements of these guidelines relevant to Australian GPs.