A GP guide to COVID-19's long-term sequelae

It is becoming increasingly evident that survivors of severe, mild and even asymptomatic COVID-19 face a large range of post-acute conditions involving almost every organ system

Need to know:

  • To date, the long-term sequelae from COVID-19 have been found to involve almost every organ system.
  • Lasting effects can occur after infection of any severity, including asymptomatic and mild cases.
  • Patients of all ages can be affected, including those with no prior comorbidities.
  • Respiratory complications are the best described, including fibrosis and reduced diffusing capacity, and restrictive ventilatory defects.
  • Neurological sequelae include acute ischaemic stroke, Guillain-Barré syndrome and transverse myelitis.
  • Myocardial inflammation and associated dyspnoea, fatigue, chest pain and palpitations may persist for months after infection onset.
  • Acute kidney injury associated with COVID-19 is typically severe and has resulted in end-stage kidney disease in a number of recovered patients with no pre-existing renal disease.
  • Rarely, children may develop a post-infectious