Obesity is generally acknowledged to be a major global health issue with associated comorbidities that can affect quality of life and life expectancy.^1,2

Interventions have largely focused on weight loss, with most recommendations involving restrictive dietary changes and intensive exercise regimens.

Evidence from long-term systematic reviews shows that, with such interventions, most individuals can successfully achieve weight loss over the short term.³ However, weight loss from behavioural interventions tends to peak at six months, followed thereafter by gradual weight regain in most individuals.^4,5

Data on long-term maintenance of weight loss, defined as a loss of ≥10% of total body weight loss maintained for ≥12 months, show that it generally only occurs in approximately 20% of individuals.^6,7