Is folate effective for methotrexate side effects?

What does the evidence say?

Clinical Scenario

Penny, a 55-year-old patient with active rheumatoid arthritis comes to the practice for weekly subcutaneous injections of methotrexate (MTX). Recently, she heard from a friend that “folic acid makes methotrexate less effective”, and she asked me: “Should I stop my folic acid tablets?”

What does the research evidence say?

Step 1: The

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