Genotyping not ready for prime time
At this time, there is insufficient evidence to support genetic testing for dose optimisation in treatment of psychiatric disorders.
Inter-individual variability in response to treatment is a major clinical problem because most psychotropic drugs, while equieffective, differ in side effects. 1
CYP450 enzymes are responsible for metabolising most psychotropic drugs 2 – the highly polymorphic CYP2D6 isoform metabolises up to 25% of common drugs, including psychotropics.