High rate of clinical trial shutdowns, study finds
Swiss researchers examined 1017 trials approved by six research ethics committees in Switzerland, Germany and Canada from 2000 to 2003, with the last follow-up being in 2013.
They found 253 (24.9%) of the trials were abandoned, and among those, the discontinuation was reported to ethics committees in only 38% of cases.
The study showed that discontinued trials were less likely than completed trials to be published, as were those with industry rather than investigator sponsorship.
Poor recruitment accounted for one in