MIMS August prescribing update

  • Exenatide (Bydureon) is an extended release microsphere formulation of exenatide. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that exhibits several antihyperglycaemic actions of GLP-1.

Exenatide suppresses glucagon secretion which is known to be inappropriately elevated in type 2 diabetes.

It is indicated for the treatment of type 2 diabetes in combination with metformin or sulfonylurea or metformin and sulfonylurea in patients who have not achieved adequate glycaemic control.

It is contraindicated in patients with end-stage renal disease or severe renal impairment (creatinine clearance < 30mL/min).

It is available as a once weekly powder for injection supplied in a carton containing four single dose kits.

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