PPIs double fracture risk – but it’s not a bone effect

Long-term use of proton pump inhibitors doubles the risk of falls and fractures in elderly women due, but the effect may be mediated by vitamin B12 rather than bone structure, Australian researchers have shown.

A University of WA study followed up more than 1000 elderly women over five years and found that long term use of PPIs was associated with a 2.17-fold higher risk of falls and fracture related hospitalisations. A second study by the same group found a 50% higher risk of falling in PPI users, but no