Response to metformin depends on genes

The glycaemic response to metformin may vary by as much as a third between individuals depending on their genes, new research has shown.

Clinicians have known for some time that blood glucose responses can vary markedly to oral hypoglycaemic drug for people with type 2 diabetes, but now researchers have shown that inherited traits play a role in the response.

In a Scottish study of 2085 people with diabetes taking metformin, they found that glycaemic responses to the drug varied significantly according to their phenotype. The