Technique predicts who benefits from tPA

US researchers have developed a tool that may help pinpoint which stroke patients will benefit most from intravenous tPA and which ones are more likely to suffer intracranial haemorrhage if given the drug.

The method combines dedicated software with an MRI scan on patients suffering acute iscaemic stroke to detect how much gladonium (used in perfusion-weighted imaging) leaks into the brain tissue, indicating the extent of damage to the blood-brain barrier.

Data from 75 stroke patients showed the amount of damage to the blood-brain barrier detected correlated well with the degree of intracranial haemorrhaging they had after administration of tPA.

The method predicted haemorrhaging with 95% accuracy