6 things to know about treating Paget's disease

IN PAGET'S disease, a disorganised increase in bone formation compensates for excessive bone resorption. It can be asymptomatic.

  1. Treatment is needed for patients with symptoms such as bone pain and neurological complications, and should be considered for some asymptomatic patients; for example, if younger than 50 years or with active disease.
  2. Therapeutic Guidelines: Endocrinology says bisphosphonates are the main treatment. They can reduce bone remodelling to near normal. The bisphosphonates are not equally effective. Oral