6 things to know about treating Paget's disease
IN PAGET'S disease, a disorganised increase in bone formation compensates for excessive bone resorption. It can be asymptomatic.
- Treatment is needed for patients with symptoms such as bone pain and neurological complications, and should be considered for some asymptomatic patients; for example, if younger than 50 years or with active disease.
- Therapeutic Guidelines: Endocrinology says bisphosphonates are the main treatment. They can reduce bone remodelling to near normal. The bisphosphonates are not equally effective. Oral