Can this CAM compound help with knee pain?

While palmitoylethanolamide (PEA) might be plausible for osteoarthritis, more research is needed

Fatima, 59, a woman living with painful knee osteoarthritis was brought in by her daughter, a pharmacy assistant.


Fatima's case was previously described in Examining the Evidence.

In this consultation she raised a new ‘natural’ treatment, palmitoylethanolamide (PEA), for osteoarthritis.

I recognised this substance from discussion on an online GP forum, with several members having had patients prescribed it by a pain physician.